Episodes like 'Mr. Garrison's Fancy New Vagina' ridicule sex change surgery and its regrets alongside racial identity swaps for sports advantage; 'Die Hippie, Die' lampoons leftist hippie culture as an infestation; 'Two Days Before the Day After Tomorrow' skewers global warming hysteria and media panic; 'Follow That Egg!' has the post-op Mrs. Garrison opposing gay marriage; 'Ginger Kids' parodies victimhood and supremacist movements from any group; and 'Trapped in the Closet' dismantles Scientology while joking about celebrity closets.

Controversies arose from offended Scientologists and Catholics over religious mockery, not from any 'woke' elements, with creators Trey Parker and Matt Stone maintaining their libertarian, equal-opportunity offending style. Casting remains true to the show's crude, traditional setup with no DEI mandates or forced diversity. Reception was strong, including an Emmy win, with no audience backlash decrying wokeness—proving its focus on unfiltered comedy over messaging.