The season's serialized storyline revolves around internet trolling (Gerald Broflovski as Skankhunt42 leading chaotic troll wars), nostalgic 'Member Berries' manipulating the election (satirizing blind nostalgia and political incompetence), gender conflicts between boys and girls (mocking hypersensitivity and absurd protests like 'wieners out'), and Mr. Garrison's Trump-like presidential run. PC Principal, carried over from Season 19, attempts to mediate gender peace with figures like Bill Clinton, but his efforts are depicted as futile and overly aggressive, serving as a caricature of SJW ineffectiveness rather than endorsement.

Elements like Caitlyn Jenner's satirical VP run are punchlines, not focal points of normalization or exploration. Casting remains consistent with longstanding characters—no race/gender swaps, forced diversity, or prominent LGBTQ+ arcs driving the narrative. Creators Trey Parker and Matt Stone use the season to lampoon political chaos and online culture without activist intent, resulting in criticism for repetitiveness and over-serialization, not 'wokeness.' This purity of uncompromised satire, free from progressive intrusions, preserves the show's entertaining core appeal.