Casting remains consistent with core voice actors Seth MacFarlane, Alex Borstein, Mila Kunis, and Seth Green, plus diverse guest stars like Johnny Depp and Jon Hamm, but no DEI-mandated changes, race/gender swaps, or identity-focused prominence. Minor progressive-adjacent elements include a single episode critiquing pharmaceutical corporate greed by withholding a cancer cure, and explorations of sexuality such as Meg's infatuation with a gay teen leading to her drugging Chris for a threesome, handled in crass, non-affirming ways that mock rather than lecture.

Other touches like Peter converting to Islam only to discover his friend's terrorism (Turban Cowboy) rely on stereotypes offensive to progressive sensitivities. No creator interviews emphasize activism or inclusion; reception focuses on declining quality and formulaic humor, with one episode delayed post-Sandy Hook for sensitivity but no widespread backlash over wokeness. Overall, any social elements are incidental, satirical, and subordinate to entertainment, aligning with the show's tradition of offending all sides.