The standout factor is Alexis Meade (born Alexander), Daniel's sibling who transitioned and returns with amnesia about it; multiple episodes feature her adjusting to life post-transition, an advertiser threatening to pull ads unless the transsexual sister is fired, and family conflicts over her identity. This representation stems from a deliberate adaptation change—the original Colombian telenovela kept the sibling male—placing a trans character and related acceptance/discrimination arcs front and center in several storylines.

Additional threads include challenges to conventional beauty standards through Betty's unapologetic style and workplace competence, plus incidental diversity in the ensemble cast reflecting New York demographics. These elements influence character arcs and subplots without dominating the fish-out-of-water comedy or romantic focus.

Creator intent around inclusion is evident in the choice to feature the trans storyline for visibility at the time, though execution includes period-typical dialogue and conflicts now viewed critically. Audience reception at launch was largely positive for its handling of identity themes, with limited contemporary backlash.