Creators Dennis Heaton and Shelley Eriksen explicitly aimed for a 'broader diversity' in the cast, avoiding 'monochromatic superhero' archetypes, resulting in leads like South Asian asexual queer genetics student Abbi Singh (Rhianna Jagpal), Latino chupacabra-shifter Juan Ruiz (Iñaki Godoy), and white banshee Tilda Weber (Morgan Taylor Campbell). Abbi's asexuality is overtly stated on-screen, contrasted ironically with her pheromone powers inducing attraction, and features a romantic subplot with another woman, Hannah Moore, which queer outlets like Autostraddle celebrate as rare ace/queer WOC rep.

Additional elements include a non-binary mad scientist antagonist (Dr. Sarkov) and diverse ensemble.

These influence character arcs and team dynamics but remain subplots to the central sci-fi horror premise of mutated twenty-somethings hunting their unethical gene-therapist amid eugenics and monstrosity themes. While not the foundational driver—replaced by powers and revenge—the prominence of layered identities (ace, queer, POC in STEM) and creator-stated inclusion intent marks significant ideological integration, though without overt lectures or backlash.