The primary drivers remain combat, survival, and personal relationships within the established sci-fi lore of genetic engineering for population sustainability. Izana Shinatose, a third-gender character initially neither male nor female who transforms into a female after developing feelings for Nagate, features in subplots involving body changes, a wardrobe malfunction confirming her new anatomy, and a romantic arc that resolves heteronormatively.

Tsumugi Shiraui, a new original human-Gauna hybrid bio-weapon voiced by Aya Suzaki, adds a romantic interest and emotional crisis elements but functions as an organic sci-fi creation tied to prior events with Hoshijiro. These elements appear as world-building extensions rather than narrative drivers or activist statements.

No established characters undergo race, gender, or sexuality swaps, and creator intent from the Nihei manga emphasizes hard sci-fi deconstruction over contemporary identity politics. Audience reception highlights action, character growth, and romance shifts without widespread claims of ideological prioritization.