Supporting characters include incidental diversity such as black neighbor Cleveland Brown and wheelchair-bound Joe Swanson, whose disability is portrayed positively in one episode where he heroically saves the day, but these elements feel organic to a Rhode Island suburb setting without clashing or dominating narratives. Satirical bits mock cultural appropriation (Peter pretending to be Native American for casino profits) and animal mistreatment (Brian's dog show ordeal), but serve humor rather than advocacy or lectures on systemic issues.

No race-swapping, gender-swapping, or forced LGBTQ+ representation; core casting is white-dominated with no DEI influence. Creator Seth MacFarlane's intent was boundary-pushing offensive comedy akin to The Simpsons or South Park, not progressive activism. Reception lauded the sharp humor and originality, with minor controversies over offensive jokes like anti-Catholicism or 'Canada sucks,' but zero backlash for wokeness or identity politics—critics noted indecency, not inclusion mandates.