Matthew explores his gay sexual preferences in detail, including questioning top/bottom roles and navigating experiences with bisexual Jay, while Jessi practices enthusiastic consent and the group encounters a Compassion Pachyderm teaching empathy and perspective-taking. Episodes directly address porn consumption, consent communication, and identity exploration as core plot drivers rather than incidental subplots.

Creators have stated the series aims to preach inclusivity, educate on female pleasure, asexuality, and consent as the world changed, with the final season reinforcing these through mailbag Q&A on sex and a finale emphasizing acceptance of unique identities. The Missy recast from white voice actor Jenny Slate to Black actor Ayo Edebiri for racial authenticity adds a layer of deliberate representational adjustment to an established character. Audience and critic responses highlight the show's trailblazing LGBTQ focus and sex-ed messaging, though the heavy emphasis on these elements in the concluding season elevates their centrality beyond organic storytelling.