The standout is episode 5, 'The Planned Parenthood Show,' where students stage skits promoting the organization's services including contraceptives, pap smears, STD testing, vasectomies, and abortion access; creators Nick Kroll, Mark Levin, and Jennifer Flackett met with Planned Parenthood leadership, toured a clinic, and framed the episode as intentional advocacy to counter stigma, with meta dialogue thanking the 'liberal elite' for pushing the story despite expected backlash. Episode 7 'Guy Town' has boys and fathers explicitly debating 'what it means to be a man' amid critiques of toxic masculinity.

Additional threads include girls' body insecurity from early breast development, the Shame Wizard amplifying shame around sexuality, and expanded roles for gay character Matthew plus diverse voice casting including Jordan Peele and Maya Rudolph. Creators stated intent to explore evolving gender and sexuality stories beyond core puberty gags.

These elements influence subplots and one full episode without redefining the entire raunchy premise, though the dedicated advocacy segment and creator statements elevate centrality. Audience and critic reception split along expected lines, with praise for 'maturity' alongside conservative pushback labeling the Planned Parenthood episode preachy liberal messaging.