Its plots revolve around survival decisions such as passenger votes for a supreme leader, resource rationing through Guaranteed versus Pioneers splits, AI ranking algorithms for threats, and a missile launch from Earth's TOTOPOTUS tech-bros council. These elements lampoon universal absurdities without centering identity politics, systemic oppression, or social justice activism as narrative drivers.

Creator Armando Iannucci has described the series as examining group think and behavior by amplifying contemporary follies, explicitly shifting focus beyond direct politics toward shared human error in the vein of his earlier work on Veep. As an original series, Avenue 5 introduces no established-character race or gender swaps and avoids source-material alterations. Its cast appears in organic fashion that reflects modern society without foregrounding messaging or DEI mandates.

Thematic emphasis stays fixed on elections, corporate buffoonery, and media immersion, with no prominent LGBTQ+ focal points, patriarchy critiques, or identity-driven conflicts shaping the stories. This approach keeps progressive elements minimal and incidental, resulting in the low woke score.