Themes of class division and systemic inequality between the wealthy, tech-driven Piltover and the oppressed, polluted Zaun drive the core conflict, influencing character arcs like the sisters Vi and Powder/Jinx caught between pacifism (Vander) and revolution (Silco), presented in a nuanced, centrist manner that critiques corruption on both sides without heavy-handed lectures. Subtle but clear romantic tension between Vi and Caitlyn introduces LGBTQ+ representation, building organically into their partnership without dominating the narrative.

Strong female protagonists abound, but male characters like Silco and Jayce are complex and capable, avoiding overt emasculation. Creators focused on storytelling fidelity to the game over explicit activism in interviews. Reception was overwhelmingly positive with universal acclaim and awards, escaping major anti-woke backlash as an example where inclusion feels natural and story prioritizes entertainment, though some critics noted the class messaging and sapphic subtext as woke-leaning.