The plot revolves around male models Derek and Hansel reuniting to thwart a conspiracy involving pop star assassinations and a mythical Fountain of Youth tied to their bloodline, featuring over-the-top cameos and physical comedy. Casting preserves established characters like Derek (Ben Stiller), Hansel (Owen Wilson), and Mugatu (Will Ferrell) without race, gender, or sexuality alterations, with new additions like Penelope Cruz as a capable Interpol agent/model feeling organic to the genre.

A non-binary model character (All, played by Benedict Cumberbatch) appears briefly as part of the 'evolved' fashion world but is portrayed as a cartoonish stereotype, sparking pre-release boycott calls from LGBTQ activists for transphobia rather than praise for representation—creators like Justin Theroux defended it, and Cumberbatch later reflected it backfired. No feminist framing, systemic oppression narratives, or creator-stated activist intent; reception lambasted the film for unfunny execution and irrelevance, not wokeness, allowing pure entertainment focus unmarred by contemporary social justice activism.