The protagonist Bethany Sloane, an abortion clinic counselor revealed as the last scion through her direct descent from Jesus, receives her mission from the angel Metatron and teams with the prophets Jay and Silent Bob, the overlooked apostle Rufus, and the muse Serendipity. Her personal struggles with infertility and faith loss integrate naturally into the plot as consequences of her heritage, providing motivation without external ideological imposition. Kevin Smith draws on his Catholic background to deliver traditional satire targeting religious institutions and blind adherence to rules, exemplified by the "Buddy Christ" rebranding campaign led by Cardinal Glick.

The inclusion of performers such as Chris Rock as Rufus serves the story's humorous take on biblical omissions rather than advancing contemporary identity frameworks, while the overall ensemble reflects the era's comedic casting without altering established lore or centering modern political themes. This approach keeps the focus on critiquing dogma itself, resulting in minimal progressive messaging.