Supporting characters like Miles Morales appear as new original figures introduced organically through the plot, with no race or gender swaps of established canon characters. The story focuses on classic villains (Kingpin, Doc Ock, Mr. Negative) and themes of responsibility without systemic oppression framing or identity politics as central conflicts. Pride flags function only as static environmental props in the open-world NYC map to reflect real-world setting authenticity, while developer statements stress realistic diverse representation through civil rights tributes and a Pride mural without narrative mandates or consultancy involvement.

Minor side content includes a fan-requested straight marriage proposal Easter egg and background diversity that does not influence main plot, arcs, or gameplay systems. Reception shows no critic-audience score gap on Metacritic (87 critics / ~8.7-8.9 users) and centers on gameplay and story fidelity rather than ideology.