The protagonist, the Hunter, is explicitly non-gendered with they/them pronouns used exclusively in all dialogue, and character creation offers unlabeled body types (male/female) plus extensive customization that ignores traditional gender norms for hairstyles and facial hair. Caretaker is a gender-flipped composite character (originally male in Ghost Rider comics lineage) placed in a long-term sapphic romance with Agatha Harkness, with the game foregrounding her mourning of that relationship. Magik is portrayed as pansexual per her 2020 comic confirmation, and the Deadpool DLC emphasizes his queer identity and "queer chaos." These choices influence character arcs, subplots, and player immersion without forming the core premise of fighting Lilith via tactics and friendships.