Players control five original characters—Detective John Murphy, Professor Dr. Clawstone, Witch Elizabeth dez Flèches, Thief Michelle Ricci, and a ghoul—each with distinct combat styles and storylines centered on investigating the Mythos, battling cultists and monsters like Mi-Go or Cthulhu, and managing sanity. These characters are new creations for the game, not alterations to established Lovecraft figures, and their gender mix serves gameplay variety rather than any ideological statement. The core premise, randomly generated levels drawn from stories like those involving forbidden experiments or jungle rituals, and mechanics such as knowledge collection to confront Great Old Ones remain rooted in traditional horror tropes of cosmic insignificance and dread.