It stars the established Elric brothers Edward and Alphonse on a quest involving chimeras, the Philosopher's Catalyst, and equivalent exchange themes, alongside supporting characters like Armony Eiselstein and Professor Wilhelm Eiselstein. The narrative follows classic FMA conventions of adventure, alchemy combat, and brotherly bonds without any modern social justice framing, identity politics, or critiques of traditional norms.

The game uses the fixed cast and world from the source material with no character creation systems, romance options, pronoun selections, or casting changes that alter established identities. This approach keeps thematic focus squarely on alchemy rules, moral consequences of human transmutation, and the brothers' central relationship rather than any ideological messaging. Developer choices avoided activist consultations, progressive marketing angles, or added subplots centered on identity, resulting in content that aligns entirely with the original manga and anime's adventure-driven structure. Audience reception at the time centered on gameplay and story fidelity rather than cultural debates, confirming the absence of forced contemporary elements.